Publicaciones CSD-brainage

Hacia la diagnosis preclínica y el tratamiento de la Enfermedad de Alzheimer.

Antonell A, Lladó A, Altirriba J, Botta-Orfila T, Balasa M, Fernández M, Ferrer I, Sánchez-Valle R, Molinuevo JL. "A preliminary study of the whole-genome expression profile of sporadic and monogenic early-onset Alzheimer's disease." Neurobiology of Aging, 34:1772-1778 (2013).

Molinuevo JL, Gispert JD, Pujol J, Rojas S, Lladó A, Balasa M, Antonell A, Sánchez-Valle R, Rami L. "Una nueva aproximación en el diagnóstico de la enfermedad de Alzheimer con biomarcadores: descripción del AD-CSF-Index." Revista de Neurología 54:513-22 (2012).

Molinuevo JL, Gispert JD, Dubois B, Heneka M, Lleo A, Engelborghs S, Pujol J, Cruz de Souza L, Alcolea D, Jessen F, Sarazin M, Lamari F, Balasa M, Antonell A, Rami L. "The AD-CSF-index discriminates between Alzheimer's disease patients from healthy controls: a validation study." Journal of Alzheimers Disease, in press (2013).

Solé-Padullés C, Bartrés-Faz D, Lladó A, Bosch B, Peña-Gómez C, Castellví M, Rami L, Bargalló N, Sánchez-Valle R, Molinuevo JL."Donepezil Treatment Stabilizes Functional Connectivity During Resting State and Brain Activity During Memory Encoding in Alzheimer's Disease." Journal of Clinical Psychopharmacology, 33:199-205 (2013).

Silvia Gil-Navarro, Francisco Lomeña, Albert Cot, Albert Lladó, Nuria Montagut, Magdalena Castellví, Beatriz Bosch, Lorena Rami, Anna Antonell, Mircea Balasa, Javier Pavia, Alex Iranzo, José Luis Molinuevo, Raquel Sánchez-Valle."Decreased striatal dopamine transporter uptake in the non-fluent/agrammatic variant of primary progressive aphasia" European Journal of Neurology, in press (2013).

Antonell A, Gil S, Sánchez-Valle R, Balasa M, Bosch B, Prat MC, Chiollaz AC, Fernández M, Yagüe J, Molinuevo JL, Lladó A. Serum progranulin levels in patients with frontotemporal lobar degeneration and Alzheimer's disease: detection of GRN mutations in a Spanish cohort. J Alzheimers Dis. 2012;31(3):581-91. doi: 10.3233/JAD-2012-112120. PubMed PMID: 22647257.

Sala-Llonch R, Fortea J, Bartrés-Faz D, Bosch B, Lladó A, Peña-Gómez C, Antonell A, Castellanos-Pinedo F, Bargalló N, Molinuevo JL, Sánchez-Valle R. Evolving brain functional abnormalities in PSEN1 mutation carriers: a resting and visual encoding fMRI study. J Alzheimers Dis. 2013 Jan 1;36(1):165-75. doi: 10.3233/JAD-130062. PubMed PMID: 23579331.

Balasa M, Vidal-Piñeiro D, Lladó A, Antonell A, Bosch B, Castellanos F, Bargalló N, Bartres-Faz D, Molinuevo JL, Sánchez-Valle R. PSEN1 mutation carriers present lower cerebrospinal fluid amyoid-β42 levels than sporadic early-onset Alzheimer's disease patients but no differences in neuronal injury biomarkers. J Alzheimers Dis. 2012;30(3):605-16. doi: 10.3233/JAD-2012-111949. PubMed PMID: 22426017.

Molinuevo JL, Sánchez-Valle R, Lladó A, Fortea J, Bartrés-Faz D, Rami L. Identifying earlier Alzheimer's disease: insights from the preclinical and prodromal phases. Neurodegener Dis. 2012;10(1-4):158-60. doi: 10.1159/000332806. Epub 2011 Dec 7. Review. PubMed PMID: 22156554.

Identificación de genes y rutas relacionadas con la susceptibilidad de diferentes zonas del cerebro al desarrollo de la enfermedad de Alzheimer. 

Martin MG, Trovò L, Perga S, Sadowska A, Rasola A, Chiara F, Dotti CG. Cyp46-mediated cholesterol loss promotes survival in stressed hippocampal neurons.Neurobiol Aging. 2011, 32:9933-943.

Sodero AO, Weissmann C, Ledesma MD, Dotti CG. Cellular stress from excitatory neurotransmission contributes to cholesterol loss in hippocampal neurons aging in vitro.Neurobiol Aging. 2011, 32: 91043-91053.

Trovò L, Van Veldhoven PP, Martín MG, Dotti CG. Sphingomyelin upregulation in mature neurons contributes to TrkB activity by Rac1 endocytosis. J Cell Sci. 2011,124(Pt 8):1308-1315.

Sodero AO, Trovò L, Iannilli F, Van Veldhoven P, Dotti CG, Martin MG.Regulation of tyrosine kinase B activity by the Cyp46/cholesterol loss pathway in mature hippocampal neurons: relevance for neuronal survival under stress and in aging. J Neurochem. 2011, 116: 747-755.

Nesic I, Guix FX, Vennekens K, Michaki V, Van Veldhoven PP, Feiguin F, De Strooper B, Dotti CG, Wahle T. Alterations in phosphatidylethanolamine levels affect the generation of Aβ.Aging Cell. 2012, 11: 63-72.

Michaki V, Guix FX, Vennekens K, Munck S, Dingwall C, Davis JB, Townsend DM, Tew KD, Feiguin F, De Strooper B, Dotti CG, Wahle T. Down-regulation of the ATP-binding cassette transporter 2 (Abca2) reduces amyloid-β production by altering Nicastrin maturation and intracellular localization.J Biol Chem. 2012, 287:1100-1111.

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoè-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG. Cholesterol loss during glutamate-mediated excitotoxicity.EMBO J. 2012, 31:1764-1773.

Guix FX, Wahle T, Vennekens K, Snellinx A, Chávez-Gutiérrez L, Ill-Raga G, Ramos-Fernandez E, Guardia-Laguarta C, Lleó A, Arimon M, Berezovska O, Muñoz FJ, Dotti CG, De Strooper B. Modification of γ-secretase by nitrosative stress links neuronal ageing to sporadic Alzheimer's disease.EMBO Mol Med. 2012, 4: 660-673.

Trovò L, Ahmed T, Callaerts-Vegh Z, Buzzi A, Bagni C, Chuah M, Vandendriessche T, D'Hooge R, Balschun D, Dotti CG. Low hippocampal PI(4,5)P₂ contributes to reduced cognition in old mice as a result of loss of MARCKS.Nat Neurosci. 2013, 16: 449-455.

Papel de los astrocitos en la pérdida cognitiva relacionada con la edad: aspectos moleculares, clínicos y de comportamiento.

Revilla S, Suñol C, García-Mesa, Y, Giménez-LLort, L, Sanfeliu C, Cristòfol R. Physical exercise improves synaptic dysfunction and recovers the loss of survival factors in 3xTg-AD mouse brain. Neuropharmacology. 2013, in press.

Rojas S, Herance JR, Gispert JD, Abad S, Torrent E, Jiménez X, Pareto D, Perpiña U, Sarroca S, Rodríguez E, Ortega-Aznar A, Sanfeliu C. In vivo evaluation of amyloid deposition and brain glucose metabolism of 5XFAD mice using positron emission tomography. Neurobiol Aging. 2013 Jul;34(7):1790-8.

García-Mesa Y, Giménez-Llort L, López LC, Venegas C, Cristòfol R, Escames G, Acuña-Castroviejo D, Sanfeliu C. Melatonin plus physical exercise are highly neuroprotective in the 3xTg-AD mouse. Neurobiol Aging. 2012 Jun;33(6):1124.e13-29.

Cristòfol R, Porquet D, Corpas R, Coto-Montes A, Serret J, Camins A, Pallàs M, Sanfeliu C. Neurons from senescence-accelerated SAMP8 mice are protected against frailty by the sirtuin 1 promoting agents melatonin and resveratrol. J Pineal Res. 2012 Apr;52(3):271-81.

Disfunción sináptica en el cerebro envejecido: implicaciones en la enfermedad de Alzheimer. 

Knafo S, Venero C, Sánchez-Puelles C, Pereda-Peréz I, Franco A, Sandi C, Suárez LM, Solís JM, Alonso-Nanclares L, Martín ED, Merino-Serrais P, Borcel E, Li S, Chen Y, Gonzalez-Soriano J, Berezin V, Bock E, Defelipe J, Esteban JA. Facilitation of AMPA receptor synaptic delivery as a molecular mechanism for cognitive enhancement.PLoS Biol. 10:e1001262. doi: 10.1371/journal.pbio.1001262, 2012.

Fernández-Monreal M, Brown TC, Royo M, Esteban JA. The balance between receptor recycling and trafficking toward lysosomes determines synaptic strength during long-term depression.J Neurosci 32, 13200-13205, 2013.

Benoist M, Palenzuela R, Rozas C, Rojas P, Tortosa E, Morales B, González-Billault C, Ávila J, Esteban JA. MAP1B-dependent Rac activation is required for AMPA receptor endocytosis during long-term depression.EMBO J 32, 2287-2299, 2013.

Ribeiro LF, Catarino T, Santos SD, Benoist M, van Leeuwen JF, Esteban JA, Carvalho AL. Ghrelin triggers the synaptic incorporation of AMPA receptors in the hippocampus.PNAS 111, E149-E158, 2014.

Disfunciones en la comunicación neurona-glia en el cerebro envejecido: impllicaciones en la EA.

Porto-Pazos AB, et al. (2011). Artificial astrocytes improve neural network performance. PLoS One. 6:e19109. DOI: 10.1371/journal.pone.0019109.

Zorec R, et al. (2012). Astroglial excitability and gliotransmission: an appraisal of Ca2+ as a signalling route. ASN Neuro. 4. pii: e00080. DOI: 10.1042/AN20110061.

Navarrete M, et al. (2012). Astrocytes mediate in vivo cholinergic-induced synaptic plasticity. PLoS Biol. 10(2):e1001259. DOI: 10.1371/journal.pbio.1001259.

Navarrete M, et al. (2012). Astrocyte calcium signal and gliotransmission in human brain tissue. Cereb Cortex. 23(5):1240-6. DOI: 10.1093/cercor/bhs122.

Pérez-Alvarez A, Araque A. (2013). Astrocyte-neuron interaction at tripartite synapses. Curr Drug Targets. 11:1220-1224.

Pérez-Alvarez A, Araque A, Martín ED. (2013). Confocal microscopy for astrocyte in vivo imaging: Recycle and reuse in microscopy. Front Cell Neurosci. DOI: 10.3389/fncel.2013.00051.

Perea G, et al. (2014). Optogenetic astrocyte activation modulates response selectivity of visual cortex neurons in vivo. Nat. Commun. 5:3262. DOI: 10.1038/ncomms4262.

Araque, A. et al. (2014). Gliotransmitters travel in time and space. Neuron (in-press).

Cambios en los lípidos de membrana del cerebro envejecido: papel en la disfunción sináptica y su relación con la enfermedad de Alzheimer.

Ledesma MD, Prinetti A, Sonnino S, Schuchman EH. Brain pathology in Niemann Pick disease type A: insights from the acid sphingomyelinase knockout mice.J Neurochem. 2011, 116: 779-788.

Ledesma MD, Dotti CG. Peripheral cholesterol, metabolic disorders and Alzheimer's disease.Front Biosci (Elite Ed). 2012, 4:181-194.

Ledesma MD, Martin MG, Dotti CG.Lipid changes in the aged brain: effect on synaptic function and neuronal survival. Prog Lipid Res. 2012, 51: 23-35.

Agostini F, Dotti CG, Pérez-Cañamás A, Ledesma MD, Benetti F, Legname G. Prion protein accumulation in lipid rafts of mouse aging brain.PLoS One. 2013, 8:e74244.

Arroyo AI, Camoletto PG, Morando L, Sassoe-Pognetto M, Giustetto M, Van Veldhoven PP, Schuchman E, Ledesma MD. Pharmacological rescue of dendritic spine anomalies in the Niemann Pick disease type A mouse model.EMBO Mol Med In press.

Gabandé-Rodríguez E, Boya P, Labrador V, Dotti CG, Ledesma MD. High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann pick disease type A.Cell death & Diff. In press.

Homeostasis celular en el sistema nervioso. Supervivencia neuronal y desequilibrio de la autofagia durante el envejecimiento: implicaciones para enfermedades neurodegenerativas.

Rodríguez-Muela N, Koga H, García-Ledo L, de la Villa P, de la Rosa EJ, Cuervo AM, Boya P [2013] Balance between autophagic pathways preserves retinal homeostasis. Aging Cell 12:478-488

Activación del ciclo celular y de p38 MAPK en neuronas envejecidas: papel fisiológico y su relación con la enfermedad de Alzheimer.

Trempolec, N., Dave-Coll, N. and Nebreda, A.R. Snapshot - p38 MAPK Signaling. Cell 152,656-657.

Trempolec, N., Dave-Coll, N. and Nebreda, A.R. Snapshot - p38 MAPK Substrates. Cell 152,924-925.

Alteraciones cerebrovasculares en el cerebro envejecido y en la EA: relaciones con el daño isquémico.

Gubern C, Camós S, Hurtado O, Rodríguez R, Romera VG, Sobrado M, Lizasoain I, Moro MA, Lizasoain I, Serena J, Mallolas J, Castellanos M. Characterization of Gcf2/Lrrfip1 in experimental cerebral ischaemia and its role as a modulator of Akt, mTOR and β-catenin signaling pathways. Neuroscience (in press)

Ballesteros I, Cuartero MI, Pradillo JM, de la Parra J, Pérez-Ruiz A, Corbí A,Ricote M, Hamilton JA, Sobrado M, Vivancos J, Nombela F, Lizasoain I, Moro MA. Rosiglitazone-induced CD36 up-regulation resolves inflammation by PPARγ and 5-LO-dependent pathways. J Leukoc Biol. 2013 Dec 12. [Epub ahead of print] PubMed PMID: 24338629.

Cuartero MI, Ballesteros I, Moraga A, Nombela F, Vivancos J, Hamilton JA, Corbí AL, Lizasoain I, Moro MA. N2 Neutrophils, Novel Players in Brain
Inflammation After Stroke: Modulation by the PPARγ Agonist Rosiglitazone. Stroke. 2013 Dec;44(12):3498-508. doi: 10.1161/STROKEAHA.113.002470. Epub 2013 Oct 17. PubMed PMID: 24135932.

Gubern C, Camós S, Ballesteros I, Rodríguez R, Romera VG, Cañadas R, Lizasoain I, Moro MA, Serena J, Mallolas J, Castellanos M. miRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis. FEBS J. 2013 Dec;280(23):6233-46. doi: 10.1111/febs.12546. Epub 2013 Oct 28. PubMed PMID: 24112606.

Godino MC, Romera VG, Sánchez-Tomero JA, Pacheco J, Canals S, Lerma J, Vivancos J, Moro MA, Torres M, Lizasoain I, Sánchez-Prieto J. Amelioration of ischemic brain damage by peritoneal dialysis. J Clin Invest. 2013 Oct1;123(10):4359-63. doi: 10.1172/JCI67284. Epub 2013 Sep 3. PubMed PMID: 23999426; PubMed Central PMCID: PMC3784528.

Hernández-Jiménez M, Hurtado O, Cuartero MI, Ballesteros I, Moraga A, Pradillo JM, McBurney MW, Lizasoain I, Moro MA. Silent information regulator 1 protects the brain against cerebral ischemic damage. Stroke. 2013 Aug;44(8):2333-7. doi: 10.1161/STROKEAHA.113.001715. Epub 2013 May 30. PubMed PMID: 23723308.

Hurtado O, Hernández-Jiménez M, Zarruk JG, Cuartero MI, Ballesteros I, Camarero G, Moraga A, Pradillo JM, Moro MA, Lizasoain I. Citicoline (CDP-choline) increases Sirtuin1 expression concomitant to neuroprotection in experimental stroke. J Neurochem. 2013 Sep;126(6):819-26. doi: 10.1111/jnc.12269. Epub 2013 May 13. PubMed PMID: 23600725.

García-Yébenes I, Sobrado M, Moraga A, Zarruk JG, Romera VG, Pradillo JM, Perez de la Ossa N, Moro MA, Dávalos A, Lizasoain I. Iron overload, measured as serum ferritin, increases brain damage induced by focal ischemia and early reperfusion. Neurochem Int. 2012 Dec;61(8):1364-9. doi: 10.1016/j.neuint.2012.09.014. Epub 2012 Oct 2. PubMed PMID: 23036361.

Hurtado O, Ballesteros I, Cuartero MI, Moraga A, Pradillo JM, Ramírez-Franco J, Bartolomé-Martín D, Pascual D, Torres M, Sánchez-Prieto J, Salom JB, Lizasoain I, Moro MA. Daidzein has neuroprotective effects through ligand-binding-independent PPARγ activation. Neurochem Int. 2012 Jul;61(1):119-27. doi: 10.1016/j.neuint.2012.04.007. Epub 2012 Apr 11. PubMed
PMID: 22521773.

Sobrado M, Ramirez BG, Neria F, Lizasoain I, Arbones ML, Minami T, Redondo JM, Moro MA, Cano E. Regulator of calcineurin 1 (Rcan1) has a protective role in brain ischemia/reperfusion injury. J Neuroinflammation. 2012 Mar 7;9:48. doi: 10.1186/1742-2094-9-48. PubMed PMID: 22397398; PubMed Central PMCID: PMC3325863.

Zarruk JG, Fernández-López D, García-Yébenes I, García-Gutiérrez MS, Vivancos J, Nombela F, Torres M, Burguete MC, Manzanares J, Lizasoain I, Moro MA. Cannabinoid type 2 receptor activation downregulates stroke-induced classic and alternative brain macrophage/microglial activation concomitant to
neuroprotection. Stroke. 2012 Jan;43(1):211-9. doi: 10.1161/STROKEAHA.111.631044. Epub 2011 Oct 20. PubMed PMID: 22020035.